Heart failure duration progressively modulates the arrhythmia substrate through structural and electrical remodeling
نویسندگان
چکیده
منابع مشابه
Altered connexin43 expression produces arrhythmia substrate in heart failure.
Recently, we found that repolarization heterogeneities between subepicardial and midmyocardial cells can form a substrate for reentrant ventricular arrhythmias in failing myocardium. We hypothesized that the mechanism responsible for maintaining transmural action potential duration heterogeneities in heart failure is related to intercellular uncoupling from downregulation of cardiac gap junctio...
متن کاملStructural and electrical ventricular remodeling in rat acute myocarditis and subsequent heart failure.
OBJECTIVE We reported that experimental autoimmune myocarditis (EAM) rats showed dramatic changes in ventricular action potential and enhanced arrhythmogenicity in the acute phase, but mechanisms for this are still unclear. To investigate the mechanisms of cardiac remodeling in acute myocarditis and subsequent heart failure, physiological and molecular changes were evaluated along the time cour...
متن کاملAging Modulates the Substrate and Triggers Remodeling in Atrial Fibrillation.
Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial ...
متن کاملElectrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans.
BACKGROUND Atrial fibrillation (AF) frequently complicates congestive heart failure (CHF). However, the electrophysiological substrate for AF in humans with CHF remains unknown. We evaluated the electrophysiological and electroanatomic characteristics of the atria in patients with CHF. METHODS AND RESULTS Twenty-one patients (aged 53.7+/-13.6 years) with symptomatic CHF (left ventricular ejec...
متن کاملArrhythmia and structural abnormalities of the fetal heart.
Thirty fetuses with cardiac arrhythmias were referred for ultrasonography. This included cross sectional and M mode echocardiography and pulsed Doppler analysis of the fetal heart. Three types of arrhythmias were observed: ectopic beats, tachyarrhythmias, and bradycardia. Ectopic beats were associated with cardiac structural abnormalities in two cases, resulting in fetal death in one. Tachycard...
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ژورنال
عنوان ژورنال: Life Sciences
سال: 2015
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2014.12.024